John Searle’s Chinese Room Argument purports to demonstrate that syntax is not sufficient for semantics, and, hence, because computation cannot yield understanding, the computational theory of mind, which equates the mind to an information processing system based on formal computations, fails. In this paper, we use the CRA, and the debate that emerged from it, to develop a philosophical critique of recent advances in robotics and neuroscience. We describe results from a body of work that contributes to blurring the divide (...) between biological and artificial systems; so-called animats, autonomous robots that are controlled by biological neural tissue and what may be described as remote-controlled rodents, living animals endowed with augmented abilities provided by external controllers. We argue that, even though at first sight, these chimeric systems may seem to escape the CRA, on closer analysis, they do not. We conclude by discussing the role of the body–brain dynamics in the processes that give rise to genuine understanding of the world, in line with recent proposals from enactive cognitive science. (shrink)

The co-occurrence of stress-induced posttraumatic stress disorder (PTSD) and obesity is common, particularly among military personnel but the link between these conditions is unclear. Individuals with comorbid PTSD and obesity manifest other physical and psychological problems, which significantly diminish their quality of life. Current understanding of the pathways connecting stress to PTSD and obesity is focused largely on behavioral mediators alone with little consideration of the biological regulatory mechanisms that underlie their co-occurrence. In this work, we leverage prior knowledge to (...) systematically highlight such bio-behavioral mechanisms and inform on the design of confirmatory pilot studies. We use natural language processing (NLP) to extract documented regulatory interactions involved in the metabolic response to stress and its impact on obesity and PTSD from over 8 million peer-reviewed papers. The resulting network describes the propagation of stress to PTSD and obesity through 34 metabolic mediators using 302 documented regulatory interactions supported by over 10,000 citations. Stress jointly affected both conditions through 21 distinct pathways involving only two intermediate metabolic mediators out of a total of 76 available paths through this network. Moreover, oxytocin (OXT), Neuropeptide-Y (NPY), and cortisol supported an almost direct propagation of stress to PTSD and obesity with different net effects. Although stress upregulated both NPY and cortisol, the downstream effects of both markers are reported to relieve PTSD severity but exacerbate obesity. The stress-mediated release of oxytocin, however, was found to concurrently downregulate the severity of both conditions. These findings highlight how a network-informed approach that leverages prior knowledge might be used effectively in identifying key mediators like OXT though experimental verification of signal transmission dynamics through each path will be needed to determine the actual likelihood and extent of each marker’s participation. (shrink)

In this paper, I investigate how different views about the vertical and horizontal structure of reality affect the debate between reductive and nonreductive physicalism. This debate is commonly assumed to hinge on whether there are high-level, special-science properties that are distinct from low-level physical properties and whether the alleged multiple realizability of high-level properties establishes this. I defend a metaphysical interpretation of nonreductive physicalismin the absence of both of these assumptions. Adopting an independently motivated, discipline-relative account of natural properties and (...) appealing to a phenomenon I call “multiple determinativity,” in which a single physical property simultaneously realizes different kinds of special-science properties, is sufficient to show that some special-science properties are irreducible to physical properties and that nonreductive physicalism is not merely a terminological variant of reductive physicalism. (shrink)

In this paper, I answer a fundamental question facing any view according to which natural selection is a population‐level causal process—namely, how is the causal process of natural selection related to, yet not preempted by, causal processes that occur at the level of individual organisms? Without an answer to this grounding question, the population‐level causal view appears unstable—collapsing into either an individual‐level causal interpretation or the claim that selection is a purely formal, statistical phenomenon. I argue that a causal account (...) of realization provides an answer to the grounding question. By applying this account of realization to the natural selection of melanism in rock pocket mice, I show how an alternative, formal account of realization, favored by proponents of the statistical interpretation, misses biologically important features. More generally, this paper shows how metaphysical issues about realization normally discussed in the philosophy of mind apply to debates in philosophy of biology. Thus, it is a first step toward fleshing out the oft‐noted similarities between debates in these areas. (shrink)

Kant is gaining popularity in business ethics because the categorical imperative rules out actions such as deceptive advertising and exploitative working conditions, both of which treat people merely as means to an end. However, those who apply Kant in this way often hold businesses themselves morally accountable, and this conception of collective responsibility contradicts the kind of moral agency that underlies Kant's ethics. A business has neither inclinations nor the capacity to reason, so it lacks the conditions necessary for constraint (...) by the moral law. Instead, corporate policies ought to be understood as analogous to legal constraints. They may encourage or discourage certain actions, but they cannot determine a person's maxim - which for Kant is the focus of moral judgment. Because there is no collective intention apart from any intentions of the individual agents who act as members of the corporation, an organization itself has no moral obligations. This poses a dilemma: either apply the categorical imperative to the actions of particular businesspeople and surrender the notion of collective responsibility, or apply a different moral theory to the actions of businesses themselves. Given the diffusion of responsibility in a bureaucracy, the explanatory usefulness of collective responsibility may force business ethicists to abandon Kant's moral philosophy. (shrink)

A wealth of research in social psychology indicates that various ethically arbitrary situational factors exert a surprisingly powerful influence on moral conduct. Empirically-minded philosophers have argued over the last two decades that this evidence challenges Aristotelian virtue ethics. John Doris, Gilbert Harman, and Maria Merritt have argued that situationist moral psychology – as opposed to Aristotelian moral psychology – is better suited to the practical aim of helping agents act better. The Aristotelian account, with its emphasis on individual factors, invites (...) too much risk of morally bad conduct insofar as it ignores the power of situational factors which lead us astray. Moral agents are often better off detecting and intervening on situational factors to help themselves act better. This paper offers an argument against the claim that situationism enjoys practical advantages over Aristotelian virtue ethics. There is empirical evidence suggesting that people can improve their behavior via Aristotelian strategies of deliberate self-improvement. This evidence also suggests that focusing our ethical attention on morally trivial factors may result in worse overall conduct. Accordingly, Aristotelianism may fare better than situationism on the practical issue of moral improvement. (shrink)

This response (a) integrates non-equilibrium evolutionary genetic models, such as coevolutionary arms-races and recent selective sweeps, into a framework for understanding common, harmful, heritable mental disorders; (b) discusses the forms of ancestral neutrality or balancing selection that may explain some portion of mental disorder risk; and (c) emphasizes that normally functioning psychological adaptations work against a backdrop of mutational and environmental noise. (Published Online November 9 2006).

Postcolonial science studies entails ostensibly contradictory critical and empirical commitments. Science studies scholars influenced by Bruno Latour and Isabelle Stengers embrace forms of realist, radical empiricism, while postcolonial studies scholars influenced by Jacques Derrida trace the limits of the knowable. This essay takes their common use of the term cosmopolitics as an unexpected point of departure for reconciling Derrida’s program with Stengers’s and Latour’s. I read Derrida’s critique of hospitality and Stengers’s and Latour’s ontological politics as necessary complements for conceiving (...) a care-oriented subalternist cosmopolitics, a process of composing common worlds that remains attentive to the limits of representation. (shrink)

Non-reductive physicalists have long held that the special sciences offer explanations of some phenomena that are objectively superior to physical explanations. This explanatory “autonomy” has largely been based on the multiple realizability argument. Recently, in the face of the local reduction and disjunctive property responses to multiple realizability, some defenders of non-reductive physicalism have suggested that autonomy can be grounded merely in human cognitive limitations. In this paper, I argue that this is mistaken. By distinguishing between two kinds of abstraction (...) I show that the greater explanatory relevance of some special science predicates (to certain explananda) is both non-anthropocentric and not solely based on considerations of multiple realizability. This shows that the explanatory autonomy of the special sciences is safe from the local reduction and disjunctive property strategies, even if they are successful responses to the multiple realizability argument. (shrink)

Several philosophers, known as situationists, have argued that evidence in social psychology threatens to undermine Aristotelian virtue ethics. An impressively large amount of empirical evidence suggests that most people do not consistently act virtuously and lack the ability to exercise rational control over their behavior. Since possessing moral virtues requires these features, situationists have argued that Aristotelianism does not accurately describe the character traits possessed by most people, and so the theory cannot lay claim to various theoretical advantages such as (...) explanatory power and egalitarian character education. In contrast to previous defenses which either downplay the relevance of psychological evidence or revise philosophical conceptions of virtue to fit the data, this paper appeals to previously neglected psychological evidence on self-efficacy and mental contrasting in combination with “non-idealized” interpretations of Aristotelian moral virtue to support the view that the available empirical evidence is compatible with widespread possession of virtuous character. These “non-idealized” interpretations of virtuous character allow for serious deviations from virtuous conduct, especially in the contexts described by the psychology experiments. Furthermore, decades of research on mental contrasting and self-efficacy suggest that subjects in the psychology experiments acted for reasons and possessed the ability to exercise rational control over their behavior. Hence, situationists are mistaken in thinking that, based on the empirical data, Aristotelianism is deprived of various theoretical advantages. (shrink)

When consumers choose to abstain from purchasing meat, they face some uncertainty about whether their decisions will have an impact on the number of animals raised and killed. Consequentialists have argued that this uncertainty should not dissuade consumers from a vegetarian diet because the “expected” impact, or average impact, will be predictable. Recently, however, critics have argued that the expected marginal impact of a consumer change is likely to be much smaller or more radically unpredictable than previously thought. This objection (...) to the consequentialist case for vegetarianism is known as the “causal inefficacy” (or “causal impotence”) objection. In this paper, we argue that the inefficacy objection fails. First, we summarize the contours of the objection and the standard “expected impact” response to it. Second, we examine and rebut two contemporary attempts (by Mark Budolfson and Ted Warfield) to defeat the expected impact reply through alleged demonstrations of the inefficacy of abstaining from meat consumption. Third, we argue that there are good reasons to believe that single individual consumers—not just consumers in aggregate—really do make a positive difference when they choose to abstain from meat consumption. Our case rests on three economic observations: (i) animal producers operate in a highly competitive environment, (ii) complex supply chains efficiently communicate some information about product demand, and (iii) consumers of plant-based meat alternatives have positive consumption spillover effects on other consumers. (shrink)

This article explores the ethical concept of neutrality through use of a psychiatric clinical vignette. In this case a psychiatry resident is faced with the treatment of a patient who was found by the FBI to be in possession of child pornography. Although not accused of any other crimes, the patient was a fugitive from the law and requesting treatment for pedophilia. Faced with the pressures of limited resources and anxiety about the patient's dangerousness to others, the resident and his (...) supervisor tried to strike a balance between the ethical principles of neutrality and beneficence. Through this vignette, the importance of neutrality, as well as how it can be compromised by other pressures such as expediency and anxiety, is explored. (shrink)

This essay traces the ontological and political limits of Bruno Latour’s conceptualization of the ‘common world’. Latour formulates this concept in explicating how modernist scientific and political institutions require a metaphysical foundation that is anti-democratic in rigidly partitioning nature from society. In the stead of nature/society, Latour proposes a ‘cosmopolitics’ in which we recognize our embroilment in systems comprised of heterogeneous human and nonhuman actors, and seek to innovate appropriate procedures for governing such systems and composing a more peaceful common (...) world. However, feminist and postcolonialist science studies scholars have argued that Latour’s project fails to apprehend the experiences of subjects marginalized by scientific and political structures of representation. Thus, science studies scholars seem to be faced with a problem; to avoid ontological dissonance and contradiction in integrating Latour’s program with feminist and postcolonialist critiques we must defer his claims that the cosmopolitical program entirely supersedes contemporary social movements and oppositional politics. I offer an alternative. Namely, I argue that Latour’s formulations of cosmopolitics’ procedures and the common world’s boundaries actually require an incipient model of the limits of democratic representation. I modify Latour’s proposed system of representation by reading it against Dipesh Chakrabarty’s concept of ‘subaltern pasts’, which are unassimilable to academic historical narratives (in their attribution of agency to nonhuman gods, for example). This reading emphasizes how Latour does not adequately theorize and politicize the partially autonomous reality of those excluded from the common world and thus fails to attend to how this externalization replicates the violence of modernist representational institutions. (shrink)

Abtract: This article argues that the debate between reductive and nonreductive physicalists is best characterized as a disagreement about which properties are natural. Among other things, natural properties are those that characterize the world completely. All physicalists accept the “completeness of physics,” but this claim contains a subtle ambiguity, which results in two conceptions of natural properties. Reductive physicalists should assert, while nonreductive physicalists should deny, that a single set of low-level physical properties is natural in both of these senses. (...) This way of drawing the distinction succeeds where previous approaches have failed and illuminates why the debate about reductionism is important. (shrink)

«Why forbid the tree?» Of all the questions that arise from a reading of the Genesis protology, that over why God forbade Adam and Eve the fruit of the tree of knowledge is of perennial curiosity. The present article examines the exegesis of two second-century sources, Theophilus of Antioch and Irenaeus of Lyons, each of whom considered the question of profound importance in anthropological and soteriological reflections. An emphasis on the prohibition as a test in Theophilus meets the alternate interpretation (...) of the prohibition as a formative construct in defining the limits of human intellectual capability according to Irenaeus. These are explored in detail, and at the article's end are synthesised in a reading of the Genesis prohibition that makes use of both points of emphasis. (shrink)

Several philosophers (e.g., Ehring (Nous (Detroit, Mich.) 30:461–480, 1996 ); Funkhouser (Nous (Detroit, Mich.) 40:548–569, 2006 ); Walter (Canadian Journal of Philosophy 37:217–244, 2007 ) have argued that there are metaphysical differences between the determinable-determinate relation and the realization relation between mental and physical properties. Others have challenged this claim (e.g., Wilson (Philosophical Studies, 2009 ). In this paper, I argue that there are indeed such differences and propose a “mechanistic” account of realization that elucidates why these differences hold. This (...) account of realization incorporates two distinct roles that mechanisms play in the realization of mental (and other special science) properties which are implicit, but undeveloped, in the literature—what I call “constitutive” and “integrative” mechanisms. I then use these two notions of mechanism to clarify some debates about the relations between realization, multiple realizability, and irreducibility. (shrink)

Recently Robert Forman has attempted to muster support for the largely abandoned position that mystical experiences cross-culturally include an unmediated, non-relative core. To reopen the debate he has solicited essays from likeminded scholars for his book, The Problem of Pure Consciousness. Predictably the focus of the volume rests on the refutation of the position most notably expounded by Steven Katz in his influential article of 1978, ‘Language, Epistemology and Mysticism’.

Once we accept anyone's postulates he becomes our professor and our god: for his foundations he will grab territory so ample and so easy that, if he so wishes, he will drag us up to the clouds. Montaigne During the last fifteen years, the community of philosophers interested in religion has evinced a waxing concern with the justificatory value of religious experiences for theism. Two parallel but largely discrete debates have appeared in the literature.

This article argues that the turn to the animal is a return to mythology. By reading multispecies scholarship as narrativization of contemporary mythology, I claim that the field voices anxieties about human futures through figures of animal others. Multispecies ethnography implicitly grapples with an apocalyptic mythos prevailing in the wake of modernity’s seemingly abandoned dreams (e.g. geopolitical peace, postcolonial development, environmental consciousness, economic prosperity, public understanding of science). I reconsider the cultural function of multispecies research through two moves. First, I (...) read Thom van Dooren’s Theory, Culture & Society article on ‘Authentic Crows’ as such a quasi-allegorical account. Second, I develop how animal anthropology captures the contemporary mythos in an ‘affirmationist’ register that counters the pessimistic affect of late industrialism. Ultimately, the critical politics of such research may be redeemed through efforts to work closely with scientists and to render explicit the accounts’ situatedness within late-industrial mythology. (shrink)

In AFTERLIVES OF AFFECT, Watson considers the life and work of Mayanist Linda Schele (1942 - 1988) as an entry point to discuss the nature of cultural inquiry and the metaphor of decipherment in anthropology. Watson figures Schele as a trickster guide in his experimental, person-centered ethnography, reanimating the work of decipherment and drawing upon an "affect of discovery" that better expresses the affective engagement of anthropologists and their subject of study. Through her archive, Watson finds an archaeologist wholly animated (...) by her fieldsite and immersed in a more "spiritual science," though nonetheless still imbricated in a system of settler-colonial knowledge production. By holding Schele's work in conversation with both her own interlocutors and prominent voices in the field today, Watson refocuses on anthropologists who are engaged as individuals; carrying their own attachments with them as they describe, interpret, and decipher what they observe, and in doing so, positions affective engagement as a constitutive element in a more reflexive anthropology. The book is organized into six chapters that progress thematically through Schele's life and Watson's autoethnographic reflections on his own research. In Sacrilege (chapter 1), Watson draws together moments throughout his research where he felt his exhumation of Schele's work veered too closely to disturbing what was laid to rest-much like Schele's own work, which relied on the unearthing of sites long laid to rest, reanimating long-dead Mayan rulers and artists. The chapter sets the tone of the work as always toeing the line and risking the introduction of the mystical and affective into scientific interpretation-edgewalking with Schele. In Animals (chapter 2), Watson draws upon metaphors in the animal world, as did Schele when she sought inspiration for her next moment of insight; spider webs present a Geertzian metaphor for webs of signification, while rabbits are trickster guides, a transtemporalizing technology, drawing Schele (and Watson) forward and back through time. Through these reflections, Watson builds iteratively on arguments throughout the book that return to themes more recognizable in contemporary theory conversations: more-than-human worlds, the question of modernity, and the social conditions of knowledge production. This book will be of interest to readers in anthropology, especially those engaged in the ontological turn and more-than-human worlds, as well as the history of anthropology and anthropology theory more broadly. This book will also be of interest to readers in science studies, the posthumanities, and affect theory. (shrink)

In recent years, scholars have documented the racial disparities of mass incarceration. In this paper we argue that, although retributivism and deterrence theory appear to be race-neutral, in the contemporary U.S. context these seemingly contrary theories function jointly to rationalize racial inequities in the criminal justice system. When people of color are culturally associated with criminality, they are perceived as both irresponsible and hyperresponsible, a paradox that reflects their status as what Charles Mills calls subpersons. Following from this paradox, criminality (...) is understood as an atemporal characteristic of people of color, such that they are conceived as pre-criminals, criminals, or post-criminals. In Frantz Fanon’s account, overdetermination expresses this exclusion of people of color from full agency by capturing them within a rigid, immutable essence, which then controls the social meaning of their actions. The backward-looking quality of retribution and the forward-looking quality of deterrence then treat people of color as more deserving of punishment (and more severe punishment) and as threats to the social order who have to be restrained. We should read the racialization of mass incarceration as a symptom of how precariously people of color participate in the social contract and as reflections of how theories of punishment have been racially deployed. (shrink)

Current theoretical account of judgment has a difficult time saying anything positive about the experience of judging and, when they do offer positive accounts, they seem to overlook much that we know about the capacity already in our daily lives. Following the work of Martin Heidegger and Hubert Dreyfus, this article provides a phenomenological consideration of the structure of judging that considers judgment not as an intellectual act, but as a comportment. The article proceeds in two parts. The first offers (...) a brief consideration of the assumptions of intellectualist accounts and shows why, ultimately, they may be unable to bring judging into focus. The second section offers a phenomenological account of judging. The argument of section two is that deliberate judgment is a continuation of the structure of judgment understood as comportment and, in turn, that intellectualist accounts come onto the scene too late. (shrink)

I argue that Sartre’s philosophy can be both broadened in its aspirations and deepened in its implications through dialogue with the life sciences. Section 1 introduces the philosophical terrain. Section 2 explores Sartre’s evolving understanding of nature and human relations with nature. Section 3 explores Sartre’s perspectives on scientific inquiry, natural history, and dialectical reason. Section 4 outlines recent developments in the life sciences that bear directly on Sartre’s quiet curiosity about a naturalistic dialectics. Section 5 suggests how these developments (...) constitute progress toward an “ecologized” dialectical philosophy consistent with Sartre’s mature ontology of praxis and pertinent to addressing the burgeoning socioecological crisis. (shrink)

Recently, many philosophers of religion have sought to defend the rationality of religious belief by shifting the burden of proof onto the critic of religious belief. Some have appealed to extraordinary religious experience in making their case. Religious Experience, Justification, and History restores neglected explanatory and historical considerations to the debate. Through a study of William James, it contests the accounts of religious experience offered in recent works. Through reflection on the history of philosophy, it also unravels the philosophical use (...) of the term justification. Matthew Bagger argues that the commitment to supernatural explanations implicit in the religious experiences employed to justify religious belief contradicts the modern ideal of human flourishing. (shrink)

The conception of subjectivity that dominates the Western philosophical tradition, particularly during the Enlightenment, sets up a simple dichotomy: either the subject is ultimately autonomous or it is merely a causally determined thing. Fichte and Freud challenge this model by formulating theories of subjectivity that transcend this opposition. Fichte conceives of the subject as based in absolute activity, but that activity is qualified by a check for which it is not ultimately responsible. Freud explains the behavior of the self in (...) terms of biological drives and social pressures, yet both forces are actively interpreted by the subject itself. The tensions that arise from these very different approaches show that both Fichte and Freud are trying to overcome this deeply imbedded dichotomy between freedom and determinism. Although some would respond to these tensions by trying to forge a Hegelian synthesis, such a resolution covers over the paradoxical nature of finite subjectivity. (shrink)

This essay revisits the question of Sartre's method with particular emphasis on the posthumously published Notebooks for an Ethics , Critique of Dialectical Reason ( Volume II ), and “Morale et histoire.” I argue that Sartre's method—an ever-evolving though never seamless blend of phenomenological description, dialectical analysis, and logical inference—is at once the seed and fruit of his mature ontology of praxis. Free organic praxis, what Sartre more than once calls “the human act,” is neither closed nor integral, but is (...) rather intrinsically open-ended and integrative. Thus a philosophical method that seeks at once to illuminate human experience and human history must itself be both a reflection and inflection of the essential openness and integrativity of praxis itself. In the conclusion, I argue that the openness and integrativity of Sartre's method are its core strengths and the sources of its continued philosophical worth. (shrink)

This chapter contains sections titled: The Purpose of Marriage Consent and Coercion Mail‐Order Marriages as the Kantian Ideal Treating Mail‐Order Brides Merely as Means Attempts to Criticize Mail‐Order Marriages from a Kantian Perspective Are Mail‐Order Brides Coerced? Questioning the a priori Basis of Kant's Ethics Notes toward a Genealogy of Kantianism.

The Fractured Self in Freud and German Philosophy examines Freud's transformation of German philosophical approaches to freedom, history, and self-knowledge; defends a theory of situated knowledge and agency; and considers the relevance of Freudian thought for contemporary cultural issues.

This article attempts to show that Heidegger’s phenomenology may shed light on political phenomena. It pursues this project by arguing that Heidegger’s phenomenology is an appropriation of Aristotle’s practical philosophy and his conceptualization of phronesis. I argue that, in Being and Time, Heidegger’s ‘circumspection’, which is a capacity for making sense of practical situations, is a translation of phronesis. Heidegger argues, though, that the sight of circumspection is foreshortened by the rules and norms of ‘the one’. In division 2, ‘conscience’ (...) becomes a sharpening of the vision of phronesis, which sees through the one. I then defend Heidegger’s appropriation of phronesis and argue that Heidegger’s concept of conscience, which takes up a critical stance toward plurality, may actually be a proper vision of practical wisdom under modern conditions. I substantiate this claim by turning to an unlikely source to bolster Heidegger’s reading of phronesis and the modern public, Hannah Arendt. (shrink)

Given that natural selection is so powerful at optimizing complex adaptations, why does it seem unable to eliminate genes (susceptibility alleles) that predispose to common, harmful, heritable mental disorders, such as schizophrenia or bipolar disorder? We assess three leading explanations for this apparent paradox from evolutionary genetic theory: (1) ancestral neutrality (susceptibility alleles were not harmful among ancestors), (2) balancing selection (susceptibility alleles sometimes increased fitness), and (3) polygenic mutation-selection balance (mental disorders reflect the inevitable mutational load on the thousands (...) of genes underlying human behavior). The first two explanations are commonly assumed in psychiatric genetics and Darwinian psychiatry, while mutation-selection has often been discounted. All three models can explain persistent genetic variance in some traits under some conditions, but the first two have serious problems in explaining human mental disorders. Ancestral neutrality fails to explain low mental disorder frequencies and requires implausibly small selection coefficients against mental disorders given the data on the reproductive costs and impairment of mental disorders. Balancing selection (including spatio-temporal variation in selection, heterozygote advantage, antagonistic pleiotropy, and frequency-dependent selection) tends to favor environmentally contingent adaptations (which would show no heritability) or high-frequency alleles (which psychiatric genetics would have already found). Only polygenic mutation-selection balance seems consistent with the data on mental disorder prevalence rates, fitness costs, the likely rarity of susceptibility alleles, and the increased risks of mental disorders with brain trauma, inbreeding, and paternal age. This evolutionary genetic framework for mental disorders has wide-ranging implications for psychology, psychiatry, behavior genetics, molecular genetics, and evolutionary approaches to studying human behavior. (Published Online November 9 2006) Key Words: adaptation; behavior genetics; Darwinian psychiatry; evolution; evolutionary genetics; evolutionary psychology; mental disorders; mutation-selection balance; psychiatric genetics; quantitative trait loci (QTL). (shrink)

This programmatic essay sketches a few reasons for the elusive nature of conscious experience. It proposes that while neither introspection nor phenomenologically refined reflection delivers direct ‘observational’ access to intrinsic features of conscious experience, intrinsic features of consciousness, nonetheless, manifest themselves in our experience in a liminal way. Overall it proceeds in two movements. Negatively, it argues that implicit self-awareness renders any notion of reflective access methodologically superfluous but existentially irresistible. Positively, it argues that ‘reflective’ access to the liminal dimensions (...) of conscious experience should be construed in purely semantic terms, tied to indirect experiential acquaintance. It concludes by suggesting that what goes by the name mental transparency, even its strong versions, does not rule out liminal manifestation: mental transparency is not mental invisibility. (shrink)

Mutagenesis makes it possible to examine the effect of amino acid replacements on the folding and stability of proteins. The evaluation of kinetic and equilibrium folding data using reaction coordinate diagrams allows one to determine the roles that single amino acids play in the folding mechanism.

Drosophila imaginal discs (appendage primordia) have proved invaluable for deciphering cellular and molecular mechanisms of animal development. By combining the accessibility of the discs with the genetic tractability of the fruit fly, researchers have discovered key mechanisms of growth control, pattern formation and long‐range signaling. One of the principal experimental attractions of discs is their anatomical simplicity — they have long been considered to be cellular monolayers. During larval stages, however, the growing discs are 2‐sided sacs composed of a columnar (...) epithelium on one side and a squamous ‘peripodial’ epithelium on the other. Recent studies suggest important roles for peripodial epithelia in processes previously assumed to be confined to columnar cell monolayers. BioEssays 23:691–697, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

"The greatest crisis of our times in a failure of the human imagination." -Editors The world is currently undergoing a period of unprecedented crises on virtually every front: economic, ecological, and humanitarian. It is starkly apparent that a shift is needed in our dominant structural systems - and that by addressing the collective thinking that has created and maintained these systems, scholars can do their part to catalyze such a shift. The interdisciplinary field known as the Anthropology of Consciousness offers (...) important insights for enacting this necessary shift. This book draws on the work of a group of diverse scholars to explore what the intersection of anthropology and consciousness studies can contribute to the "public turn" within anthropology and the academy in general. Its twelve chapters span disparate geographies and disciplinary frameworks, yet cohere in their focus on common themes such as imagination, empathy, agency, dialogue, and ethics. The answers to the question "So What? Now What?" differ for a linguistic anthropologist in the South Pacific, an environmental educator in Hawai'i, a grant-writing anthropologist serving a refugee agency in Portland, Oregon and the founder of a girls' school in Brazil. Nevertheless, they are united in the desire to reframe the anthropology of consciousness as an "anthropology of conscience," and this pioneering volume is the result. (shrink)

Influences on social traits involve a tangled interplay of genetic, social, and environmental factors. Moreover, there is increasing awareness that gene–environment correlations are real and potentially measurable. Such gene–environment correlations can mislead if they are uncontrolled and genetic associations are interpreted as being purely because of direct genetic effects. This complexity is cause for more and better investigation, not a reason to refrain from researching one of the potentially important factors (genetics) influencing trait variation.

The ticking bomb case is meant to challenge absolute prohibitions on the use of torture. In “Imaginary Cases,” Michael Davis attempts to show that such cases can only be legitimately employed within certain limited parameters. In this paper, I explain how the ticking bomb case, suitably revised, does not run afoul of Davis’s prohibition on impossible content. The fact that torture could elicit the necessary information is enough; we need not stipulate a guaranteed result. I also defend philosophers’ use of (...) the case to identify our moral intuitions and to evaluate our theoretical assumptions. Although our responses to actual events are better at mapping our actual commitments, imaginary events can also reveal our pre-theoretic intuitions. Ultimately, however, I reject the use of the ticking bomb case on practical grounds, because the imaginary case distorts our moral reasoning in actual cases and leads to our acceptance of torture more generally. (shrink)

What methodology should philosophers follow? Should they rely on methods that can be conducted from the armchair? Or should they leave the armchair and turn to the methods of the natural sciences, such as experiments in the laboratory? Or is this opposition itself a false one? Arguments about philosophical methodology are raging in the wake of a number of often conflicting currents, such as the growth of experimental philosophy, the resurgence of interest in metaphysical questions, and the use of formal (...) methods. This outstanding collection of specially-commissioned chapters by leading international philosophers discusses these questions and many more. It provides a comprehensive survey of philosophical methodology in the most important philosophical subjects: metaphysics, epistemology, philosophy of language, philosophy of mind, phenomenology, philosophy of science, ethics, and aesthetics. A key feature of the collection is that philosophers discuss and evaluate contrasting approaches in each subject, offering a superb overview of the variety of methodological approaches - both naturalistic and non-naturalistic - in each of these areas. They examine important topics at the heart of methodological argument, including the role of intuitions and conceptual analysis, thought experiments, introspection, and the place that results from the natural sciences should have in philosophical theorizing. The collection begins with a fascinating exchange about philosophical naturalism between Timothy Williamson and Alexander Rosenberg, and also includes contributions from the following philosophers: Lynne Rudder Baker, Matt Bedke, Greg Currie, Michael Devitt, Matthew C. Haug, Jenann Ismael, Hilary Kornblith, Neil Levy, E.J. Lowe, Kirk Ludwig, Marie McGinn, David Papineau, Matthew Ratcliffe, Georges Rey, Jeffrey W. Roland, Barry C. Smith, Amie L. Thomasson, Valerie Tiberius, Jessica Wilson, and David W. Smith. (shrink)

"This book argues for a mixed view of punishment that balances consequentialism and retributivism. He has published extensively on philosophy and applied ethics. A central question in the philosophy of law is why the state's punishment of its own citizens is justified. Traditionally, two theories of punishment have dominated the field: consequentialism and retributivism. According to consequentialism, punishment is justified when it maximizes positive outcomes. According to retributivism, criminals should be punished because they deserve it. This book defends a mixed (...) view that recognizes the strength of both of these intuitions. By this account, the legislature should develop institutional policies and statutory penalties that maintain the social order, that is, consequentialism. It establishes punishment policies to deter criminal activity. By contrast, the criminal judiciary should give individual defendants what they deserve, that is, retributivism and thus expressing the community's appropriate sense of resentment at being wronged. The book justifies the two-tiered model by showing how it accords with our moral intuitions, our assumptions about how what we know affects our moral obligations, and a commonly held theory of freedom. This approach is developed by engaging classic and contemporary work in the philosophy of law, and shows its advantages over competing approaches from contemporary retributivists and other mixed theorists. The work also defends consequentialism against a longstanding objection that the social sciences give us little guidance regarding which policies to adopt. It draws on cutting-edge criminological research to show how punishment theory can help us to address some of our most pressing social issues, including the death penalty, drug laws, and mass incarceration. The book will also be of interest to legal philosophers, social scientists, especially criminologists, sociologists, economists, and political scientists"--. (shrink)

: This article argues that conceptions of community after Dewey despair of an institutional means of recovering individuality, which is the central problem of democracy. They so despair, I contend, because of their politicized view of the individual. I first briefly consider the contrast between Dewey and contemporary proceduralists and civic republicans, before turning to my central discussion: C. Wright Mills, whose critique indicates a historical watershed for Dewey's view of community. Ultimately, despair of a Deweyan sense of community issues (...) in a contemporary stalemate between what I identify as the political "activist" and "apathist.". (shrink)